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Cat. No.	Product Name	Target	Signaling Pathways
T10174	5-R-Rivaroxaban	Factor Xa	Metabolism
	5-R-Rivaroxaban 是一种 Rivaroxaban 的 R 型对映体。其中 Rivaroxaban 是选择性的Factor Xa(FXa) 抑制剂。
T4980	Betrixaban maleate	Factor Xa	Metabolism
	Betrixaban maleate 是一种非维生素 K 口服抗凝剂，其作用是由 Xa 因子的竞争性和可逆抑制作用驱动的。
T1184	Rivaroxaban BAY 59-7939,利伐沙班	Factor Xa; Thrombin	Metabolism; Proteases/Proteasome
	Rivaroxaban (BAY 59-7939) 是高效选择性的凝血因子 Xa (FXa) 直接抑制剂，IC50=0.7 nM，Ki 为 0.4 nM。
T1736	Apixaban 阿哌沙班,BMS-562247-01	Factor Xa	Metabolism
	Apixaban (BMS-562247-01) 是一种高度选择性，可逆的、口服具有活力的凝血因子 Xa (Factor Xa) 抑制剂，抑制人和兔凝血因子 Xa 的 Ki 分别为 0.08 nM 和 0.17 nM。它可以用于研究各种血栓栓塞疾病。
T0372	Gabexate mesylate 甲磺酸加贝酯,FOY	Factor Xa; Serine Protease; Proteasome	Metabolism; Proteases/Proteasome; Ubiquitination
	Gabexate mesylate (FOY) 是一种非抗原的类胰蛋白酶丝氨酸蛋白酶抑制剂。
T4341	Betrixaban 贝曲西班,PRT054021	Factor Xa	Metabolism
	Betrixaban (PRT054021) 是一种口服具有活力的选择性factor Xa(fXa) 抑制剂，IC50=1.5 nM。
T22323	Enoxaparin sodium	Thrombin	Proteases/Proteasome
	Enoxaparin sodium 是一种低分子量肝素 (LMWH)，已获得美国 FDA 批准，可用于医疗管理的 ST 段心肌梗死 (STEMI) 或 STEMI 及随后的经皮冠状动脉介入治疗 (PCI) 患者。它与抗凝血酶结合并增强其作用，并抑制凝血因子 XIa、IXa、Xa 和 IIa（凝血酶），从而防止血栓形成。
T31206	Darexaban YM 150,Darexaban, Tanexaban,YM150	Factor Xa	Metabolism
	Darexaban (Tanexaban, YM-150) 是选择性的、口服具有活力的 Xa 因子 (FXa) 抑制剂，IC50=54.6 nM。它对其他相关丝氨酸蛋白酶(如胰蛋白酶、凝血酶和激肽释放酶)具有高选择性。它具有抗凝和抗血栓形成作用。
T8362	Benzamidine hydrochloride Benzamidine HCl,苄脒盐酸盐	Serine/threonin kinase; Serine Protease	Cell Cycle/Checkpoint; Metabolism; Proteases/Proteasome
	Benzamidine hydrochloride (Benzamidine HCl) 是可逆的胰蛋白酶样丝氨酸蛋白酶 (trypsin-like serine proteases) 竞争性抑制剂，对 uPA、类胰蛋白酶、胰蛋白酶和 Xa 因子作用的Ki 分别为 97 µM、20 µM、21 µM 和 110 µM。
T4076	Fondaparinux sodium Natural heparin pentasaccharide Sodium,Fondaparin sodium,磺达肝素(癸)钠,磺达肝癸钠,SR-90107A,Arixtra	Factor Xa	Metabolism
	Fondaparinux sodium (SR-90107A) 是抗凝血酶依赖性的 factor Xa 抑制剂。
T2368	Edoxaban Tosylate Monohydrate DU-176b,DU-176b tosylate Monohydrate,Lixiana,Edoxaban,依度沙班对甲苯磺酸盐一水化合物	Factor Xa; Thrombin	Metabolism; Proteases/Proteasome
	Edoxaban Tosylate Monohydrate (DU-176b tosylate Monohydrate) 是口服具有活力的 factor Xa 选择性抑制剂。它是一种抗凝剂，可用于预防中风，是一种凝血酶和凝血因子 IXaβ (FIXa) 的弱抑制剂，对 FXa 的选择性超过 10000 倍。它具有抗血栓形成的特性，可用于血栓栓塞性疾病的研究。
T67853	Rivaroxaban Impurity Rivaroxaban-10	Factor Xa	Metabolism
	Rivaroxaban Impurity (Rivaroxaban-10) 是一种强效凝血因子Xa 抑制剂，IC50=66 nM。
T27257	EMD-503982 EMD 503982
	EMD-503982 is a factor Xa inhibitor.
T20454	4-Chlorophenylurea NSC12971,NSC 12971,NSC-12971,4-氯苯基脲	Factor Xa	Metabolism
	4-Chlorophenylurea (NSC-12971) 是一种新型口服生物可利用的 Xa 因子抑制剂。
T27920	LY 517717 LY-517717,LY517717	Factor Xa	Metabolism
	LY 517717 是一种具有口服活性的凝血因子 Xa 抑制剂，具有抗血栓活性，可用于研究静脉血栓栓塞（VTE）。
T31668	Eribaxaban PD 348292,PD0348292,PD-0348292,PD-348292,PD 0348292,PD348292	Factor Xa	Metabolism
	Eribaxaban (PD348292) 是一种可口服的 Xa 因子抑制剂，可用于预防和治疗静脉血栓栓塞。
T27318	Fidexaban CI-1031,BX-807834,PD-200022,CI1031,BX807834,ZK-807834	Factor Xa	Metabolism
	Fidexaban (CI1031) 是一种新型、强效、选择性和口服活性 Xa 因子抑制剂，在多种测定中均显示出抗血栓活性。
T4690	Betrixaban hydrochloride(330942-05-7(free base)) PRT054021 hydrochloride,盐酸贝曲西班	Factor Xa	Metabolism
	Betrixaban hydrochloride(330942-05-7(free base)) (PRT054021 hydrochloride) 是一种有效的、选择性的、口服有效的 Xa 因子 (fXa) 抑制剂 (IC50: 1.5 nM)。
T29215	Zifaxaban TY 602,TY602,TY-602	Factor Xa	Metabolism
	Zifaxaban (TY-602) 是一种具有口服活性、竞争性和选择性的 Xa 因子 (FXa) 抑制剂，对人 FXa 的 IC50 为 11.1 nM。Zifaxaban 的亲和力很高，比其他丝氨酸蛋白酶高 10000 倍以上。Zifaxaban 可用于研究动脉和静脉血栓形成。
T78215	Dechloro Rivaroxaban	Factor Xa; Others	Metabolism; Others
	Dechloro Rivaroxaban 是一种具有口服活性和高选择性的 Factor Xa 抑制剂。Dechloro Rivaroxaban 对人体内游离 FXa 的抑制作用显著。Dechloro Rivaroxaban 对凝血酶原以及纤维蛋白相关的 FXa 活性也有抑制效果。
T66256	Ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate	Factor Xa	Metabolism
	Ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate 对凝血因子Xa具有抑制作用，可用于研究血栓性静脉炎、动脉粥样硬化、脑栓塞、中风、肺栓塞。
T68092	Letaxaban TAK-442	Factor Xa	Metabolism
	Letaxaban (TAK-442) 是一种口服活性的四氢嘧啶-2(1H)- 1衍生物和具有抗凝血活性的凝血因子Xa(激活因子X)抑制剂。Letaxaban 不影响出血时间。Letaxaban 已被用于研究静脉血栓栓塞和急性冠状动脉综合征的治疗和预防的试验。
T2368L	Edoxaban Lixiana,依杜沙班	Factor Xa; Thrombin	Metabolism; Proteases/Proteasome
	Edoxaban (Lixiana) (DU-176) 是一种选择性的，口服有效的 factor Xa (FXa)抑制剂。Edoxaban 对游离 FXa 和凝血酶原的 Ki 分别为 0.561 nM 和 2.98 nM。Edoxaban 是一种抗凝剂，可用于预防中风。Edoxaban 还是一种凝血酶和凝血因子 IXaβ (FIXa) 的弱抑制剂，Ki 值分别为 6.00 μM 和 41.7 μM，对 FXa 的选择性超过 10000 倍。由于具有抗血栓形成的特性，Edoxaban 可用于预防血栓栓塞性疾病的研究。
T70536	Idraparinux Na
	Idraparinux Na is an Antithrombotic, Indirect, Selective, Synthetic Factor Xa Inhibitor
T27224	DX-9065A HCl hydrate DX9065,DX 9065,DX9065A,DX 9065A,DX-9065A,DX-9065
	DX-9065A is a factor Xa inhibitor. DX-9065a inhibits proinflammatory events induced by factor Xa and gingipains. DX-9065a is a competitive inhibitor of the Spectrozyme FXa (SpFXa) cleavage by both fXa and prothrombinase with similar K(i) values of approxi
T70349	DJT06001
	DJT06001 is a selective Factor Xa inhibitor, reducing thrombus formation with low risk of bleeding.
T35926	Bz-IEGR-pNA (acetate)
	Bz-IEGR-pNA is a colorimetric substrate for Factor Xa.1 Factor Xa preferentially binds to and cleaves the Ile-Glu-Gly-Arg (IEGR) peptide sequence to release p-nitroanilide (pNA), which can be quantified by colorimetric detection at 405 nm as a measure of Factor Xa activity.References1. Aruell, L., Friberger, P., Karlsson, G., et al. A new sensitive and highly specific chromogenic peptide substrate for factor Xa. Thromb. Res. 11(5), 595-609 (1977). Bz-IEGR-pNA is a colorimetric substrate for Fact...
T26793	BI-11634
	BI-11634 is a factor Xa inhibitor.
T69276	KFA1982
	KFA1982 is a novel and potent factor Xa inhibitor.
T27698	JTV-803 mesylate JTV803,JTV 803,JTV-803
	JTV-803 is a factor Xa inhibitor. JTV-803 showed a competitive inhibitory effect on human factor Xa, with a K(i) value of 0.019 microM and IC(50) value of 0.081 microM. JTV-803 was 100 times more selective in inhibiting human factor Xa as compared to its
T71096	GCC-4401C methanesulfonate
	GCC-4401C methanesulfonate is a factor Xa inhibitor similar to rivaroxaban that is currently under development for venous thromboembolic disease (VTE).
T21037	Edoxaban Isomer
	Edoxaban Isomer is an impurity of Edoxaban, which is a novel inhibitor of factor Xa.
T35931	GGACK (hydrochloride)
	GGACK is an inhibitor of urokinase-type plasminogen activator (uPA) and factor Xa (Kis = 1.8 and 8.7 μM, respectively).1,2 1.Kettner, C., and Shaw, E.The susceptibility of urokinase to affinity labeling by peptides of arginine chloromethyl ketoneBiochim. Biophys. Acta569(1)31-40(1979) 2.Kettner, C., and Shaw, E.The selective affinity labeling of factor Xa by peptides of arginine chloromethyl ketoneThromb. Res.22(5-6)645-652(1981)
TP1129	Boc-Ile-Glu-Gly-Arg-AMC IEGR-AMC
	Boc-Ile-Glu-Gly-Arg-AMC (IEGR-AMC), a specific, highly fluorogenic substrate for clotting enzyme factor Xa (coagulation factor Xa). Boc-IEGR-AMC is also hydrolyzed by acrosin from the ascidian Halocynthia roretzi.
T37054	Z-D-Arg-Gly-Arg-pNA . 2 HCl
	Z-RGR-pNA is a chromogenic substrate for the determination of factor Xa.
T23755	AS1468240 AS 1468240,AS-1468240
	AS1468240 is a factor Xa inhibitor. It has significant oral anticoagulant activity.
T27202	DPC-423 DPC-423 Free
	DPC-423 is a factor Xa inhibitor potentially for the treatment of thrombosis.
T27121	Darexaban glucuronide YM 222714,YM222714,YM-222714
	Darexaban glucuronide is the major component in plasma after oral administration of darexaban to humans. Darexaban (YM150) is a direct inhibitor of factor Xa.
T28921	Tanogitran BIBT 986,BIBT986,BIBT-986
	Tanogitran, a coagulation factor Xa inhibitor, is used potentially for the treatment of septic shock.
T12694	Razaxaban hydrochloride BMS 561389 hydrochloride,DPC 906 hydrochloride	Others	Others
	Razaxaban hydrochloride is a highly potent, selective and orally active inhibitor of factor Xa(Ki of 0.19 nM),has strongly antithrombotic activity.
T12782	RWJ-445167 3DP-10017	Factor Xa; Thrombin	Metabolism; Proteases/Proteasome
	RWJ-445167 is a thrombin and factor Xa dual inhibitor(Ki of 4.0 nM and 230 nM, respectively), with potent antithrombotic activity.
T38795	Suc-Ile-Glu(γ-pip)-Gly-Arg-pNA hydrochloride
	Suc-Ile-Glu(γ-pip)-Gly-Arg-pNA hydrochloride is a factor Xa specific chromogenic substrate.
T27514	GW-813893 GW813893,GW 813893,GSK813893,GSK-813893,GSK 813893
	GW-813893 is a potent, selective and orally active factor Xa inhibitor. GW813893 inhibited FXa and prothrombinase activity with a Ki of 4.0 nM and 9.7 nM, respectively.
T70184	YM-60828 dihydrochloride
	YM-60828 dihydrochloride is a Factor Xa (FXa) inhibitor and anticoagulant used in the treatment of venous thromboembolic disease.
T78424	CH3OCO-D-CHA-Gly-Arg-pNA acetate	Factor Xa	Metabolism
	CH3OCO-D-CHA-Gly-Arg-pNA acetate是一种用于检测factor Xa活性的显色底物。
T71429	O-Demethyl apixaban sulfate
	O-Demethyl apixaban sulfate is a metabolite of Apixaban, a potent and highly selective factor Xa inhibitor. Apixaban is currently under development for treatment of arterial and venous thrombotic diseases.
T28491	R-1663 R1663
	R-1663 is a factor Xa inhibitor. R-1663 prolonged clotting times, inhibited thrombin generation (peak height and endogenous thrombin potential [ETP]) and anti-factor Xa activity in a concentration-dependent manner without increasing bleeding time. Pharmac
T10820	Ciraparantag PER977	Others	Others
	Ciraparantag is an inhibitor of thrombin and factor Xa. Ciraparantag is a broad-spectrum reversal agent for anticoagulants, including unfractionated heparin, low-molecular-weight heparin, and certain direct oral anticoagulants.
T71362	GCC-4401C free base
	GCC-4401C free base is a factor Xa inhibitor similar to rivaroxaban that is currently under development for venous thromboembolic disease (VTE).
T37176	Edoxaban impurity 6
	Edoxaban impurity 6 is an impurity of Edoxaban. Edoxaban (DU-176) is a selective, potent and orally active factor Xa (FXa) inhibitor with Kis of 0.561 nM and 2.98 nM for free FXa and prothrombinase, respectively. Edoxaban is an anticoagulant agent and can be used for stroke prevention[1][2]. [1]. Furugohri T, et al. DU-176b, a potent and orally active factor Xa inhibitor: in vitro and in vivo pharmacological profiles. J Thromb Haemost. 2008 Sep;6(9):1542-9.[2]. Mendell J, Lee F, Chen S, The Effe...

化合物

5-R-Rivaroxaban

Cat.No: T10174

Target: Factor Xa

Betrixaban maleate

Cat.No: T4980

Target: Factor Xa

Cat.No: T1184

Synonym: BAY 59-7939,利伐沙班

Target: Factor Xa, Thrombin

Cat.No: T1736

Synonym: 阿哌沙班,BMS-562247-01

Target: Factor Xa

Gabexate mesylate

Cat.No: T0372

Synonym: 甲磺酸加贝酯,FOY

Target: Factor Xa, Serine Protease, Proteasome

Cat.No: T4341

Synonym: 贝曲西班,PRT054021

Target: Factor Xa

Enoxaparin sodium

Cat.No: T22323

Target: Thrombin

Cat.No: T31206

Synonym: YM 150,Darexaban, Tanexaban,YM150

Target: Factor Xa

Benzamidine hydrochloride

Cat.No: T8362

Synonym: Benzamidine HCl,苄脒盐酸盐

Target: Serine/threonin kinase, Serine Protease

Fondaparinux sodium

Cat.No: T4076

Synonym: Natural heparin pentasaccharide Sodium,Fondaparin sodium,磺达肝素(癸)钠,磺达肝癸钠,SR-90107A,Arixtra

Target: Factor Xa

Edoxaban Tosylate Monohydrate

Cat.No: T2368

Synonym: DU-176b,DU-176b tosylate Monohydrate,Lixiana,Edoxaban,依度沙班对甲苯磺酸盐一水化合物

Target: Factor Xa, Thrombin

Rivaroxaban Impurity

Cat.No: T67853

Synonym: Rivaroxaban-10

Target: Factor Xa

Cat.No: T27257

Synonym: EMD 503982

4-Chlorophenylurea

Cat.No: T20454

Synonym: NSC12971,NSC 12971,NSC-12971,4-氯苯基脲

Target: Factor Xa

Cat.No: T27920

Synonym: LY-517717,LY517717

Target: Factor Xa

Cat.No: T31668

Synonym: PD 348292,PD0348292,PD-0348292,PD-348292,PD 0348292,PD348292

Target: Factor Xa

Cat.No: T27318

Synonym: CI-1031,BX-807834,PD-200022,CI1031,BX807834,ZK-807834

Target: Factor Xa

Betrixaban hydrochloride(330942-05-7(free base))

Cat.No: T4690

Synonym: PRT054021 hydrochloride,盐酸贝曲西班

Target: Factor Xa

Cat.No: T29215

Synonym: TY 602,TY602,TY-602

Target: Factor Xa

Dechloro Rivaroxaban

Cat.No: T78215

Target: Factor Xa, Others

Ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate

Cat.No: T66256

Target: Factor Xa

Cat.No: T68092

Synonym: TAK-442

Target: Factor Xa

Cat.No: T2368L

Synonym: Lixiana,依杜沙班

Target: Factor Xa, Thrombin

Cat.No: T70536

DX-9065A HCl hydrate

Cat.No: T27224

Synonym: DX9065,DX 9065,DX9065A,DX 9065A,DX-9065A,DX-9065

Cat.No: T70349

Bz-IEGR-pNA (acetate)

Cat.No: T35926

Cat.No: T26793

Cat.No: T69276

JTV-803 mesylate

Cat.No: T27698

Synonym: JTV803,JTV 803,JTV-803

GCC-4401C methanesulfonate

Cat.No: T71096

Edoxaban Isomer

Cat.No: T21037

GGACK (hydrochloride)

Cat.No: T35931

Boc-Ile-Glu-Gly-Arg-AMC

Cat.No: TP1129

Synonym: IEGR-AMC

Z-D-Arg-Gly-Arg-pNA . 2 HCl

Cat.No: T37054

Cat.No: T23755

Synonym: AS 1468240,AS-1468240

Cat.No: T27202

Synonym: DPC-423 Free

Darexaban glucuronide

Cat.No: T27121

Synonym: YM 222714,YM222714,YM-222714

Cat.No: T28921

Synonym: BIBT 986,BIBT986,BIBT-986

Razaxaban hydrochloride

Cat.No: T12694

Synonym: BMS 561389 hydrochloride,DPC 906 hydrochloride

Target: Others

Cat.No: T12782

Synonym: 3DP-10017

Target: Factor Xa, Thrombin

Suc-Ile-Glu(γ-pip)-Gly-Arg-pNA hydrochloride

Cat.No: T38795

Cat.No: T27514

Synonym: GW813893,GW 813893,GSK813893,GSK-813893,GSK 813893

YM-60828 dihydrochloride

Cat.No: T70184

CH3OCO-D-CHA-Gly-Arg-pNA acetate

Cat.No: T78424

Target: Factor Xa

O-Demethyl apixaban sulfate

Cat.No: T71429

Cat.No: T28491

Synonym: R1663

Cat.No: T10820

Synonym: PER977

Target: Others

GCC-4401C free base

Cat.No: T71362

Edoxaban impurity 6

Cat.No: T37176

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